Tick-borne encephalitis (TBE) is prevalent in Europe and Far-East Russia and about 10,000 cases were reported annually. In Hokkaido, Japan, a TBE patient was found in 1993 and TBE virus was isolated from ticks, sentinel dogs and wild rodents. The results provided evidence that TBE is endemic in Hokkaido. In 2001, a Japanese traveler suffered TBE in Austria and died. TBE vaccine of Control European TBE virus is available from two companies, Baxter and Chiron. Both of the vaccines are effective to TBE virus Far-East type strain and Hokkaido strain. It is needed to have vaccination to Japanese oversee travelers to endemic countries and residents in endemic areas in Japan.